qEVシリーズ ／
細胞外小胞抽出キット2022年 第1四半期 出版物まとめ

1. アルツハイマー病に関連するアストロサイト特異的EVタンパク質

Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain.
Yang You, Satoshi Muraoka, Mark P Jedrychowski, Jianqiao Hu, Amanda K McQuade, Tracy Young-Pearse, Roshanak Aslebagh, Scott A Shaffer, Steven P Gygi, Mathew Blurton-Jones, Wayne W Poon, Tsuneya Ikezu
Jan 2022, Journal of Extracellular Vesicles .11:e12183. doi: 10.1002/jev2.12183

2. 免疫調節RNAおよび抗がん治療のための赤血球細胞外小胞 ( RBC-EV ) の有効性評価

Robust delivery of RIG-I agonists using extracellular vesicles for anti-cancer immunotherapy.
Boya Peng, Trinh Mai Nguyen, Migara Kavishka Jayasinghe, Chang Gao, Thach Tuan Pham, Luyen Tien Vu, Eric Yew Meng Yeo, Gracemary Yap, Lingzhi Wang, Boon Cher Goh, Wai Leong Tam, Dahai Luo, Minh TN Le
Wiley Online Library, Jan 2022, Journal of Extracellular Vesicles.2022;11:e12187. doi: 10.1002/jev2.12187

3. 乳がん患者のリンパ滲出液から分離した細胞外ベシクルの表面マーカーの特性評価

Characterization of surface markers on extracellular vesicles isolated from lymphatic exudate from patients with breast cancer.
Karin Ekström, Rossella Crescitelli, Hafsteinn Ingi Pétursson, Junko Johansson, Cecilia Lässer, Roger Olofsson Bagge
BMC Cancer, volume 22, Jan 2022, Article number: 50. doi: 10.1186/s12885-021-08870-w

4. より特異的で信頼性の高い small EVマーカーの探索

Tissue differences in the exosomal/small extracellular vesicle proteome and their potential as indicators of altered tissue metabolism
Ruben Garcia-Martin, Bruna Brasil Brandao, Thomas Thomou, Emrah Altindis, C Ronald Kahn
Cell Reports, 2022 Jan 18;38(3):110277. doi: 10.1016/j.celrep.2021.110277

5. 腸-免疫軸におけるsmall EVs

Gut Microbiota-Derived Small Extracellular Vesicles Endorse Memory-like Inflammatory Responses in Murine Neutrophils
Trim Lajqi, Natascha Köstlin-Gille, Stefan Hillmer, Maylis Braun, Simon A Kranig, Stefanie Dietz, Christian Krause, Jessica Rühle, David Frommhold, Johannes Pöschl, Christian Gille, Hannes Hudalla
Biomedicines, 2022 Feb 14;10(2):442. doi: 10.3390/biomedicines10020442

6. メラノーマ由来EVによるリンパ管リモデリングと腫瘍免疫

Melanoma-derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes
Noelle Leary, Sarina Walser, Yuliang He, Nikola Cousin, Paulo Pereira, Alessandro Gallo, Victor Collado-Diaz, Cornelia Halin, Susana Garcia-Silva, Hector Peinado, Lothar C Dieterich
Journal of Extracellular Vesicles, 2022 Feb;11(2):e12197. doi: 10.1002/jev2.12197

7. GFP-tagging研究におけるqEV originalカラムで採取されたEVs

GFP-tagging of extracellular vesicles for rapid process development
Braulio Carrillo Sanchez, Matthew Hinchliffe, Daniel G. Bracewell
Biotechnology Journal, 24 March 2022. doi: 10.1002/biot.202100583

8. トリプルネガティブ乳がん細胞からのEVに関連する抗腫瘍免疫応答

Extracellular vesicles from triple negative breast cancer promote pro-inflammatory macrophages associated with better clinical outcome
Mercedes Tkach, Jessie Thalmensi, Eleonora Timperi, Paul Gueguen, Nathalie Névo, Eleonora Grisard, Philemon Sirven, Federico Cocozza, Alizée Gouronnec, Lorena Martin-Jaular, Mabel Jouve, Fabien Delisle, Nicolas Manel, Derek C Rookhuizen, Coralie L Guerin, Vassili Soumelis, Emanuela Romano, Elodie Segura, Clotilde Théry
Proc Natl Acad Sci U S A , Mar 2022, PNAS.26;119(17):e2107394119. doi: 10.1073/pnas.2107394119

9. がん性と健常性の膵臓オルガノイドにおけるEVsの比較

Proteomic analysis distinguishes extracellular vesicles produced by cancerous versus healthy pancreatic organoids
Abigail C Buenafe, Craig Dorrell, Ashok P Reddy, John Klimek, Daniel L Marks
Scientific Reports , Mar 2022, 3;12(1):3556. doi: 10.1038/s41598-022-07451-6

10. T細胞活性化における腫瘍由来EVのメカニズム

The tumor-targeted CD40 agonist CEA-CD40 promotes T cell priming via a dual mode of action by increasing antigen delivery to dendritic cells and enhancing their activation
Eva Sum, Moritz Rapp, Harald Dürr, Alekhya Mazumdar, Pedro J Romero, Christine Trumpfheller, Pablo Umaña
ournal for Immunotherapy of Cancer , Mar 2022, 10(3):e003264. doi: 10.1136/jitc-2021-003264